Publications

Ruiz PD, Hamilton GA, Park JW, Gamble MJ. MacroH2A1 Regulation of Poly(ADP-Ribose) Synthesis and Stability Prevents Necrosis and Promotes DNA Repair. Mol Cell Biol. 2019 Dec 11;40(1). doi: 10.1128/MCB.00230-19. Print 2019 Dec 11. PubMed PMID: 31636161; PubMed Central PMCID: PMC6908255.

Ruiz PD, Gamble MJ. MacroH2A1 chromatin specification requires its docking domain and acetylation of H2B lysine 20. Nat Commun. 2018 Dec 3;9(1):5143. doi: 10.1038/s41467-018-07189-8. PubMed PMID: 30510186; PubMed Central PMCID: PMC6277393.

Chen H, Ruiz PD, McKimpson WM, Novikov L, Kitsis RN, Gamble MJ. MacroH2A1 and ATM Play Opposing Roles in Paracrine Senescence and the Senescence-Associated Secretory Phenotype. Mol Cell. 2015 Sep 3;59(5):719-31. doi: 10.1016/j.molcel.2015.07.011. Epub 2015 Aug 20. PubMed PMID: 26300260; PubMed Central PMCID: PMC4548812.

Chen H, Ruiz PD, Novikov L, Casill AD, Park JW, Gamble MJ. MacroH2A1.1 and PARP-1 cooperate to regulate transcription by promoting CBP-mediated H2B acetylation. Nat Struct Mol Biol. 2014 Nov;21(11):981-9. doi: 10.1038/nsmb.2903. Epub 2014 Oct 12. PubMed PMID: 25306110; PubMed Central PMCID: PMC4221384.

Gamble MJ. Expanding the functional repertoire of macrodomains. Nat Struct Mol Biol. 2013 Apr;20(4):407-8. doi: 10.1038/nsmb.2552. PubMed PMID: 23552290.

Novikov L, Park JW, Chen H, Klerman H, Jalloh AS, Gamble MJ. QKI-mediated alternative splicing of the histone variant MacroH2A1 regulates cancer cell proliferation. Mol Cell Biol. 2011 Oct;31(20):4244-55. doi: 10.1128/MCB.05244-11. Epub 2011 Aug 15. PubMed PMID: 21844227; PubMed Central PMCID: PMC3187283.